RBRC10950, C57BL/6-Tg(CAG-Sphk1)H1Ytkw

RBRC No. RBRC10950
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6-Tg(CAG-Sphk1)H1Ytkw
Former Common name Sphk1 transgenic mice (Tg line: High)
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
1 Symbol Sphk1
Symbol name sphingosine kinase 1
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cardiovasc Res. 2010 Feb 1;85(3):484-93. doi: 10.1093/cvr/cvp312
Additional information
1 No Data
Depositor Takuwa, Yoh (Kanazawa University Graduate School of Medical Science) Takuwa, Yoh
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10963, B6.129-Tg(Nanog-RFP)2Szki

RBRC No. RBRC10963
Type TransgeneCartagena
Species Mus musculus
Strain name B6.129-Tg(Nanog-RFP)2Szki
Former Common name Nanog-RFP Tg mouse
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse Nanog promoter
2 Symbol RFP
Symbol name Discosoma sp. Red Fluorescent Protein
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genesis, 57, e23334 (2019).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for-profit institution for a not-for-profit research. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Suzuki, Atsushi (Medical institute of bioregulation, Kyushu University) Suzuki, Atsushi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Live
Live mouse :

RBRC01391, ICR.Cg-Mesp2<tm5(Notch1)Ysa>/YsaRbrc

RBRC No. RBRC01391
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name ICR.Cg-Mesp2<tm5(Notch1)Ysa>/YsaRbrc
Former Common name Notch1 in Mesp2 Knock-in mice
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain ICR
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Notch1
Symbol name Notch gene homolog 1 (Drosophila)
Chromosome 7
Common name No Data
Symbol description No Data
2 Symbol Mesp2
Symbol name mesoderm posterior 2
Chromosome 7
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
References Nat Genet. 2000 Aug;25(4):390-6.

Mesp2 initiates somite segmentation through the Notch signalling pathway.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Genet., 25, 390-396, (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 Saga Lab HP
Depositor Saga, Yumiko (National Institute of Genetics) Saga, Yumiko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10741, C57BL/6-Rapgef4<tm1.1Ito>

RBRC No. RBRC10741
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-Rapgef4<tm1.1Ito>
Former Common name cAMP-GEF2 KO, CG2 KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Rapgef4
Symbol name Rap guanine nucleotide exchange factor (GEF) 4
Chromosome 2
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 2
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Brain, 8:38 (2015).
Additional information
1 No Data
Depositor Itohara, ShigeYoshi (RIKEN Center for Brain Science) Itohara, ShigeYoshi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01450, B6.129S4-Runx1<tm1Sata>/SataRbrc

RBRC No. RBRC01450
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S4-Runx1<tm1Sata>/SataRbrc
Former Common name AML1 KO, Runx1 KO mice
H-2 Haplotype No Data
Donor strain 129S4/SvJae
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Masanobu Satake, Tohoku University in 1998. A targeting vector containing pgk-neo cassette was transfered into ES cells to relpace exons 4.
Strain description B6.129S4-Runx1<tm1Sata>. Runx1, runt related transcription factor 1 (also called AML1) encodes the DNA binding subunit of the heterodimeric transcription factor. Runx1 is one of the most frequent targets of chromosome translocation associated with several subtypes of human acute myeloid or lymphoblastic leukemia. Mice homozygous for the Runx1 null mutantion die embryonic day 12.5 due to massive hemorrhage in the central nervous system. In fetal livers of mutant embryos, no hematopoieteic cells are generated.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Runx1
Symbol name runt related transcription factor 1
Chromosome 16
Common name AML1, Cbfa2, Pebp2a2, runt domain, alpha subunit 2
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name neo; neomycin;
Symbol description No Data
References Oncogene. 1998 Nov 5;17(18):2287-93.

AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.
Research applications Cancer Research,
Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 17, 2287-2293 (1998).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use
of it from the DEPOSITOR to avoid possible conflicts with DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a
citation of the following literature designated by the DEPOSITOR is requested.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE,
an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to include the DEPOSITOR as a co-author in any publications
resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Satake, Masanobu (Institute of Development, Aging and Cancer, Tohoku University) Satake, Masanobu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10761, B6.B6CB-Gsdmd<tm1.1Tshir>/Ms

RBRC No. RBRC10761
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.B6CB-Gsdmd<tm1.1Tshir>/Ms
Former Common name Gsdmd-/-, Gsdmd KO
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Gsdmd
Symbol name gasdermin D
Chromosome 15
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 15
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genesis, 46, 418-423 (2008).
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. (Contact info: Tsuyoshi Koide, Ph.D. , Mouse Genomics Resource Laboratory)
Additional information
1 No Data
Depositor Shiroishi, Toshihiko (National Institute of Genetics) Shiroishi, Toshihiko
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01471, C3H-M1

RBRC No. RBRC01471
Type Spontaneous Mutation
Species Mus musculus
Strain name C3H-M1
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Nishimura, Masahiko (Nagoya University) Nishimura, Masahiko
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10788, C57BL/6N-Eipr1<em1Card>

RBRC No. RBRC10788
Type CRISPR/Cas9
Species Mus musculus
Strain name C57BL/6N-Eipr1<em1Card>
Former Common name Tssc1KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Eipr1
Symbol name EARP complex and GARP complex interacting protein 1
Chromosome 12
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
本系統を用いて公表された第一報の論文
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent form the DEPOSITOR.
Additional information
1 No Data
Depositor Kumamoto University
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC01493, NKT clone mice 24-F4-1

RBRC No. RBRC01493
Type Other wks
Species Mus musculus
Strain name NKT clone mice 24-F4-1
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References Curr Biol. 2005 Jun 21;15(12):1114-8.

Generation of cloned mice by direct nuclear transfer from natural killer T cells.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
To clarify the purpose of using the strain of mice.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Ogura, Atsuo (RIKEN, BioResource Center) Ogura, Atsuo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Generation of cloned mice by direct nuclear transfer from natural killer T cells. Curr Biol.15(12): 1114-8 (2005).(15964276)
Inoue K, Wakao H, Ogonuki N, Miki H, Seino K, Nambu-Wakao R, Noda S, Miyoshi H, Koseki H, Taniguchi M, Ogura A.

RBRC10818, B6D2-Lvrn<em1Osb>

RBRC No. RBRC10818
Type CRISPR/Cas9 (Transgene)Cartagena
Species Mus musculus
Strain name B6D2-Lvrn<em1Osb>
Former Common name Lvrn-62/-62
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Lvrn
Symbol name laeverin
Chromosome 18
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J Reprod Dev. 2019 Jun 14;65(3):239-244.
The RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University. The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again.
Additional information
1 No Data
Depositor Ikawa, Masahito (Osaka university) Ikawa, Masahito
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months