RBRC06558, B6(D2)-Smo<Rgsc2073>

RBRC No. RBRC06558
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Smo<Rgsc2073>
Former Common name SmoG457X, B6-Smo/G457X
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Shigeru Makino and Yoichi Gondo, RIKEN BioResource center. Generated by RIKEN ENU-based gene driven mutagenesis. The mutant mice were backcrossed to C57BL/6J.
Strain description Smo gene G457X variant mice. Homozygous mutant mice die around E10.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Smo
Symbol name smoothened homolog (Drosophila)
Chromosome 6
Common name No Data
Symbol description No Data
References Nat Rev Genet. 2008 Oct;9(10):803-10.

Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Research applications Cancer Research,
Developmental Biology Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced).
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06574, B6.Cg-Tg(Chx10-cre/ERT2)G7Tfur

RBRC No. RBRC06574
Type TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Tg(Chx10-cre/ERT2)G7Tfur
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Takahisa Furukawa, Osaka Bioscience Institute in 2010. The BAC-Chx10-creERT2 transgene was injected into the pronuclei of B6C3F1 fertilized eggs.
Strain description BAC-Chx10-creERT2 transgenic mice. This transgenic mouse expresses tamoxifen-inducible cre recombinase under the control of the mouse Chx10 promoter. 129 background (RBRC05565), C57BL/6 mixed background (RBRC06574).
Colony maintenance Carrier x Carrier, Noncarrier [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA signal
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol ERT2
Symbol name estrogen receptor (ER), human ER with the triple mutation G400V/M543A/L544A)
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse Vsx2 promoter
3 Symbol cre
Symbol name Phage P1 Cre recombinase
Chromosome UN
Common name No Data
Symbol description No Data
References Unpublished

Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Furukawa, Takahisa (Osaka Bioscience Institute) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06594, C57BL/6N-Mpp6<tm1b(EUCOMM)Hmgu>/E11

RBRC No. RBRC06594
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6N-Mpp6<tm1b(EUCOMM)Hmgu>/E11
Former Common name No Data
H-2 Haplotype No Data
ES cell line JM8A3.N1 [C57BL/6N-A]
Background strain C57BL/6NTac
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Mpp6
Symbol name membrane protein, plamitoylated 6 (MAGUK p55 subfamily member 6)
Chromosome 6
Common name No Data
Symbol description No Data
2 Symbol En2
Symbol name En2 SA (mouse En2 intron 2/exon 3 splice acceptor sequence)
Chromosome 6
Common name No Data
Symbol description No Data
3 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 6
Common name No Data
Symbol description No Data
4 Symbol Ires
Symbol name internal ribosomal entry site (EMCV)
Chromosome 6
Common name No Data
Symbol description No Data
5 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 6
Common name No Data
Symbol description No Data
6 Symbol poly A
Symbol name SV40 polyadenylation site
Chromosome 6
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT should acknowledge the EUCOMM, RIKEN BRC and the International Mouse Phenotyping Consortium as the original creator of the targeted mouse ES cells and the provider of the knockout mice, respectively.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor RIKEN, BioResource Center
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09237, B6.ICR-Tg(Cdkn1a-luc)34Eiha/EihaRbrc

RBRC No. RBRC09237
Type TransgeneCartagena
Species Mus musculus
Strain name B6.ICR-Tg(Cdkn1a-luc)34Eiha/EihaRbrc
Former Common name p21-p-luc(B6), B6-p21-p-luc Tg, p21-p-luc(Acc. No. CDB0415T-34)(B6)
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Eiji Hara, The Cancer Institute, Japanese Foundation for Cancer Research. The transgene was injected into the pronuclei of ICR fertilized eggs. The mutant mice were backcrossed to C57BL/6.
Strain description human p21-luciferase transgenic mice.
Colony maintenance Carrier x Noncarrier [C57BL/6Jcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 late polyA signal
Chromosome UN
Common name No Data
Symbol description No Data
Promoter human CDKN2A promoter
2 Symbol luc
Symbol name luciferase
Chromosome UN
Common name No Data
Symbol description No Data
References Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15034-9. Epub 2007 Sep 11.

Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals.
Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from Dr. Eiji HARA (hara@genome.tokushima-u.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0415T-34 and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Proc Natl Acad Sci U S A. 2007 Sep 18; 104 (38): 15034-9. (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09253, CHe.STS-(D4Mit322-D4Mit86)

RBRC No. RBRC09253
Type Congenic
Species Mus musculus
Strain name CHe.STS-(D4Mit322-D4Mit86)
Former Common name C.S322-86, BALB-322-86
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Nobuko Mori, Osaka Prefecture University.
Strain description BALB/cHeA congenic strain carries D4Mit322-D4Mit86 genomic region from STS/A. This strain exhibits susceptibility to radiation induced thymic lymphomas.
Colony maintenance Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References http://dx.doi.org/10.5772/55159

Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
Additional information
1 No Data
Depositor Mori, Nobuko (Osaka Prefecture University) Mori, Nobuko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09298, C57BL/6N-Shank2<em1Rbrc>

RBRC No. RBRC09298
Type CRISPR/Cas9
Species Mus musculus
Strain name C57BL/6N-Shank2<em1Rbrc>
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6NTac
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Shank2
Symbol name SH3 and multiple ankyrin repeat domains 2
Chromosome 7
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT should acknowledge RIKEN BRC and the International Mouse Phenotyping Consortium for creating and providing of the knockout mice.
Additional information
1 No Data
Depositor RIKEN, BioResource Center
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09315, 129cB6-Gpr98<tm1>

RBRC No. RBRC09315
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129cB6-Gpr98<tm1>
Former Common name 129-backcrossed Vlgr1 knockout mice
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Adgrv1
Symbol name adhesion G protein-coupled receptor V1
Chromosome 13
Common name Gpr98, Mass1, Mgr1, Neurepin, VLGR1
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Neurosci Lett., 461, 190-195 (2009).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
Additional information
1 No Data
Depositor Sato, Makoto (University of Fukui) Sato, Makoto
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC09340, Hormad2(Acc.No.CDB0576K)

RBRC No. RBRC09340
Type Targeted MutationCartagena
Species Mus musculus
Strain name Hormad2(Acc.No.CDB0576K)
Former Common name No Data
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER Dr. Hiroki Kurahashi (Fujita Health University)(kura@fujita-hu.ac.jp ) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0576K and Web Site (www2.clst.riken.jp/arg/mutant%20mice%20list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested (Genes Cells. 2012 17(11):897-912.). (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
Additional information
1 No Data
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC09364, B6;129S-Igs7<tm92.1(tetO-YCX2.60)Hze>/J

RBRC No. RBRC09364
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S-Igs7<tm92.1(tetO-YCX2.60)Hze>/J
Former Common name Ai92(TITL-YCX2.60)
H-2 Haplotype No Data
ES cell line G4 [(129S6/SvEvTac x C57BL/6NCr)F1]
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA
Chromosome 9
Common name No Data
Symbol description No Data
2 Symbol F3
Symbol name yeast FRT (flippase recombination target) sites (synthetic)
Chromosome 9
Common name No Data
Symbol description No Data
3 Symbol F5
Symbol name yeast FRT (flipase recombination target) site
Chromosome 9
Common name No Data
Symbol description No Data
4 Symbol GH
Symbol name Growth hormone polyA (Bovine)
Chromosome 9
Common name No Data
Symbol description No Data
5 Symbol Igs7
Symbol name intergenic site 7
Chromosome 9
Common name No Data
Symbol description No Data
6 Symbol WPRE
Symbol name Woodchuck hepatitis virus posy-transcriptional regulatory element (WPRE)
Chromosome 9
Common name No Data
Symbol description No Data
7 Symbol loxP
Symbol name phage P1 loxP
Chromosome 9
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
8 Symbol Hyg
Symbol name hygromycin phasphotransferase (E. coli)
Chromosome 9
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system,
Fluorescent Proteins/lacZ System,
Tet system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Neuron., 85(5): 942-958 (2015).
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT agrees to acknowledge PROVIDER in all oral presentations and written publications as related to the MATERIAL and provide a copy of the publication to the DEPOSITOR.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Miyawaki Lab HP
Depositor Miyawaki, Atsushi (RIKEN Center for Brain Science) Miyawaki, Atsushi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09390, C57BL/6-Nkapl<tm1(KOMP)Vlcg>/1Htan

RBRC No. RBRC09390
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-Nkapl<tm1(KOMP)Vlcg>/1Htan
Former Common name Nkapl KO
H-2 Haplotype No Data
ES cell line VGB6 [C57BL/6NTac]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Nkapl
Symbol name NFKB activating protein-like
Chromosome 13
Common name No Data
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 13
Common name No Data
Symbol description No Data
Promoter human Ubiquitin C promoter
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The mice were originally created by the National Institutes of Health (NIH) Knock-Out Mouse Program (KOMP). The RECIPIENT is free to publish, present, display, disclose or seek patent or other intellectual property protection on any inventions arising from the use of the KOMP Materials, with no restrictions or obligations of any kind, so long as the RECIPIENT uses reasonable efforts to credit or otherwise acknowledge the KOMP as the creator of the KOMP Materials.
Additional information
1 No Data
Depositor Tanaka, Hiromitsu (Faculty of Pharmaceutical Sciences, Nagasaki International University) Tanaka, Hiromitsu
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months