|Former Common name||No Data|
|H-2 Haplotype||No Data|
|Background strain||No Data|
|1||Appearance||brachypodism and ankylosis|
|2||Appearance||severe brachypodism, ankylosis of the knee joint, and malformation with early-onset OA of the elbow joint|
|Strain description||This mutant strain carries an allele of Gdf5 gene, Gdf5<Rgsc451>,
which causes an amino acid substitution (W408R) in a highly conserved
region of the active signaling domain of the GDF5 protein.
|Symbol name||growth differentiation factor 5|
|Common name||bp, cartilage-derived morphogenetic protein-1, CDMP-1|
|Symbol description||No Data|
|References||Hum Mol Genet. 2007 Oct 1;16(19):2366-75. Epub 2007 Jul 26.|
|Research applications||Mouse Models for Human Disease|
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of for-profit institution must contact the DEPOSITOR separately.
The RECIPIENT of not for-profit institution must contact and discuss in good faith with the DEPOSITOR regarding inventorship, ownership, patent filing and licese fees and others, prior to filing a patent or make a contract with license fees with a third party for invention or products obtained from research results by using the BIOLOGICAL RESOURCES.
|1||Mouse of the Month Sep 2007|
|2||Genotyping protocol <PCR>|
|Depositor||RIKEN Genomic Sciences Center|
|Strain Status /
|A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice.||Hum Mol Genet.16(19): 2366-75 (2007).(17656374)|
|Masuya H, Nishida K, Furuichi T, Toki H, Nishimura G, Kawabata H, Yokoyama H, Yoshida A, Tominaga S, Nagano J, Shimizu A, Wakana S, Gondo Y, Noda T, Shiroishi T, Ikegawa S.|
|Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure.||Diabetes. (2013).(24062245)|
|Hinoi E, Nakamura Y, Takada S, Fujita H, Iezaki T, Hashizume S, Takahashi S, Odaka Y, Watanabe T, Yoneda Y.|
|PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.||Biochem Biophys Res Commun. (2014).(24944017)|
|Hinoi E, Iezaki T, Fujita H, Watanabe T, Odaka Y, Ozaki K, Yoneda Y.|