RBRC00045, B6C3Fe-a/a-Reln rl

RBRC No. RBRC00045
Type Spontaneous Mutation 8wks,♀
Species Mus musculus
Strain name B6C3Fe-a/a-Relnrl
Former Common name No Data
H-2 Haplotype No Data
Background strain mixed background of B6 and C3H.
Appearance
1 Appearance black, ataxic
Genotype a/a Relnrl/Relnrl
2 Appearance black, unaffected
Genotype a/a +/? or a/a Relnrl/+
Strain development This substrain of reeler mice were developed by Ogawa M (Neuron14, 1995) by extensive selection ofhomozygous breeders from original mutant mice. The strain has been maintained by sister brother mating for more than15 generations in RIKEN Tsukuba Institute.
Strain description The reeler mutation was first identified by Falconer as neurological mutant mice with abnormal locomotion (J Genet 50, 192-201, 1951) . Laminar formation of cerebral and cerebellar cortex was severely impaired in homozygous mutant mice. This mutant lacks entire Relin gene associated with large deletion of about 150kb.
Colony maintenance Heterozygous females x homozygous males, or heterozygote x heterozygote. Some homozygous females may also be used as breeders.
Health Report
Gene Details
Promoter No Data
1 Symbol Reln
Symbol name reelin
Chromosome 5
Common name No Data
Symbol description No Data
References Development. 2001 Jun;128(11):1983-93.
Nat Genet. 1995 May;10(1):77-83.
Nat Genet. 2000 Sep;26(1):93-6.
Neuron. 1995 May;14(5):899-912.
Neuron. 2001 Sep 27;31(6):929-41.
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8612-6.
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3477-82.

Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.
Research applications Developmental Biology Research,
Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Ogawa, Masaharu (RIKEN Center for Brain Science) Ogawa, Masaharu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months