RBRC00113, C3H/HeSn- Ttf/+tf

RBRC No. RBRC00113
Type Spontaneous Mutation Congenic 6wks,♂
Species Mus musculus
Strain name C3H/HeSn-Ttf/+tf
Former Common name No Data
H-2 Haplotype No Data
Background strain C3H
1 Appearance agouti, tufted (A/A, + tf/+tf)
Genotype No Data
2 Appearance agouti, tail defects, tufted (A/A, T tf/+tf)
Genotype No Data
Strain development C3H/HeSn-Ttf/+tf strain was introduced to National Institute of Genetics from the Jackson laboratory in 1985.
Strain description T, Brachyury, semidominant, Chr 17. Discovered in a laboratory stock. T/T homozygous embryos die at 10 days of gestation due to failure to form a normal mesoderm. T/+ heterozygote have a shortened tail and abnormal sacral vertebrae. T/t mice are tailless. tf/tf homozygous mice show repeated waves of hair loss and regrowth. tf gene is linked to the T/t complex.
Colony maintenance Sister-brother mating
Heterozygote x Wild (tail defects x normal tail)
Health Report No Data
Gene Details
Promoter No Data
1 Symbol T
Symbol name brachyury
Chromosome 17
Common name No Data
Symbol description No Data
2 Symbol Itpr3
Symbol name inositol 1,4,5-triphosphate receptor 3; tufted
Chromosome 17
Common name No Data
Symbol description No Data
References No Data

Research applications Dermatology Research,
Developmental Biology Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shiroishi, Toshihiko (National Institute of Genetics) Shiroishi, Toshihiko
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months