RBRC00142, B6.Cg-Kit<W-v>/Rbrc

RBRC No. RBRC00142
Type Spontaneous Mutation Congenic 8wks,♂
Species Mus musculus
Strain name B6.Cg-Kit<W-v>/Rbrc
Former Common name C57BL/6-KitW-v/+
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance white with black eyes
Genotype a/a B/B C/C W/W
2 Appearance gray with light belly, white spot, light tail an feet
Genotype a/a B/B C/C W/+
3 Appearance black
Genotype a/a B/B C/C +/+
Strain development Spontaneous mutation arosed in C57BL.
Strain description B6.Cg-Kit<W-v>. Viable dominant spotting. Spontaneous mutation arosed in C57BL. The Kit<W-v> mutation arose spontaneously in the C57BL strain. Heterozygote for Kit<W-v> are gray with light belly, white spot, light tail and feet. Homozygous mice are white with black eyes. The c-Kit cDNA from Kit<W-v>/Kit<W-v> mice showed an AC to T point mutation at nucleotide 2007 that resulted in the change from threonine to methionine at position 660.
Colony maintenance Sibling Mating (Heterozygote x Wild-type or Heterozygote)
Health Report
Gene Details
Promoter No Data
1 Symbol Kit
Symbol name kit oncogene
Chromosome 5
Common name No Data
Symbol description No Data
References Cancer Res. 1992 Apr 15;52(8):2304-9.
Mech Dev. 2001 Oct;108(1-2):213-6.

Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv).
Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv).
Research applications Cancer Research,
Dermatology Research,
Developmental Biology Research,
Endocrine Deficiency Research,
Immunology and Inflammation Research,
Mouse Models for Human Disease,
Neurobiology Research,
Reproductive Biology Research,
Sensorineural Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Kitamura, Yukihiko (Osaka University) Kitamura, Yukihiko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months