RBRC00144, C57BL/6-Ly5.1

RBRC No. RBRC00144
Type Congenic
Species Mus musculus
Strain name C57BL/6-Ly5.1
Former Common name C57BL/6-Ly-5.1
H-2 Haplotype No Data
Background strain C57BL/6
1 Appearance black
Genotype a/a B/B C/C
Strain development Deposited by Toshitada Takahashi, Aichi Cancer Center.
Strain description This is a B6 background congenic strain that having differential B cell antigen designated as Ly5.1. This strain is useful as tissue/cell and B cell markers in transplantation studies.
Colony maintenance Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol Ptprc
Symbol name protein tyrosine phosphatase
Chromosome 1
Common name B220, CD45, Cd45, CD45R, Ly-5, LY-5, Lyt-4, T200, CD45.1
Symbol description No Data
References No Data

Research applications Immunology and Inflammation Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 Mouse of the Month Jun 2009
Genetic Background
2 Genotyping protocol <PCR>
Depositor Takahashi, Toshitada (Aichi Cancer Center) Takahashi, Toshitada
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live mouse :
BRC mice in Publications
Title Journal
Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. Stem Cells.26(3): 646-55 (2008).(18079432)
Noda S, Horiguchi K, Ichikawa H, Miyoshi H.
Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6. Int J Hematol.87(3): 239-45 (2008).(18317883)
Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H.
The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation. J Immunol.182(8): 1098071 (2009).(19342670)
Mise-Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi TS.
Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. FEBS Lett.584(15): 547377 (2010).(20600007)
Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H.
Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells. Int Immunol.23(1): 65-74 (2011).(21135032)
Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K.
IL-17/IFN-gamma double producing CD8+ T (Tc17/IFN-gamma) cells: A novel cytotoxic T-cell subset converted from Tc17 cells by IL-12. Int Immunol. (2011).(22039016)
Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T.
The development of IL-17/IFN-gamma-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter. Eur J Immunol. (2012).(22674086)
Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T.
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun.4: 1836 (2013).(23673621)
Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T.
Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int Immunol. (2013).(24150243)
Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H.
NF-kappaB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain hematopoietic niche after lethal irradiation and stem cell transplantation. Int Immunol. (2014).(24908679)
Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
Mature resting Ly6Chigh natural killer cells can be reactivated by IL 15. Eur. J. Immunol.44(9): 2638-47. (2014).(24995967)
Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A.
Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): Preparation and immunological analysis of vaccine efficacy. Immunol Lett. (2014).(25479286)
Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T.
Fucci-guided purification of hematopoietic stem cells with high repopulating activity. Biochem Biophys Res Commun. (2014).(25534850)
Yo M, Sakaue-Sawano A, Noda S, Miyawaki A, Miyoshi H.
Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice Arterioscler Thromb Vasc Biol.36: 1141 (2016).(27055906)
Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K.
Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes. Mucosal Immunol. (2016).(27166558)
Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S.
Inflammasome and Fas-Mediated IL-1beta Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo. J. Immunol.199(3): 1122-1130 (2017).(28674179)
Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H.
Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model. Hepatol. Commun. (2018).(29881822)
Eiko Saijou Yutaka Enomoto Michitaka Matsuda Cindy Yuet-Yin Kok Shizuo Akira Minoru Tanaka Atsushi Miyajima.