RBRC00209, MSM/Ms

RBRC No. RBRC00209
Type Wild-derived Inbred 4wks
Species Mus musculus molossinus
Strain name MSM/Ms
Former Common name M.MOL-MSM
H-2 Haplotype No Data
Background strain MSM [Mus musculus molossinus]
1 Appearance white-bellied agouti
Genotype Aw/Aw
Strain development Developed by National Institute of Genetics.
Strain description Wild-derived inbred strain of Mus musculus molossinus, collected at Mishima, Shizuoka, Japan in April 1978 and maintained by Kazuo Mrowaki, National Institute of Genetics. This strain has been reported to be resistant to the development of lymphoma and obesity. MSM can be used to support research in many areas including cancer and genetics.
Colony maintenance Sibling x Sibling. Productive mating: 60.6% (n=53); First mating: 77.7 days (n=14); Litter size: 5.2 pups (n=102)
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References Acta Med Okayama. 1996 Dec;50(6):319-24.
Cancer Lett. 1997 Jan 1;111(1-2):97-104.
Cancer Res. 2002 Jul 1;62(13):3716-21.
Exp Anim. 1995 Jan;44(1):43-8.
Exp Anim. 2009 Apr;58(2):123-34.
Genome Res. 2004 Dec;14(12):2439-47.
Genome Res. 2008 Mar;18(3):500-8. Epub 2008 Feb 6.
Mamm Genome. 2001 Sep;12(9):750-2.
Mamm Genome. 2009 Jan;20(1):14-20. Epub 2008 Dec 12.
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10817-20.

Research applications Cancer Research,
Genetics Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. (Contact info: Tsuyoshi Koide, Ph.D. , Mouse Genomics Resource Laboratory)
Additional information
1 Mouse of the Month Apr 2009
Genetic Background
2 Click Here for Mouse genomic DNA (RIKEN DNA Bank)
Click Here for BAC clone (RIKEN DNA Bank)
Depositor Shiroishi, Toshihiko (National Institute of Genetics) Shiroishi, Toshihiko
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live mouse :
BRC mice in Publications
Title Journal
Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies Genetics166(2): 913-924 (2004).(15020476)
Oka A, Mita A, Sakurai-Yamatani N, Yamamoto H, Takagi N, Takano-Shimizu T, Toshimori K, Moriwaki K, Shiroishi T.
Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection. Mol Reprod Dev.74(9): 1081-8 (2007).(17290420)
Shinmen A, Honda A, Ohkawa M, Hirose M, Ogonuki N, Yuzuriha M, Miki H, Mochida K, Inoue K, Abe K, Ito M, Ogura A.
X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet.3(7): e116 (2007).(17676999)
Sugimoto M, Abe K.
Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp Eye Res.86(5): 828-34 (2008).(18396277)
Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H.
Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Mamm. Genome.20(1): 14-20 (2009).(19082856)
Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K.
Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Mol Ecol.19(12): 2474-89 (2010).(20465587)
Nunome M, Ishimori C, Aplin KP, Tsuchiya K, Yonekawa H, Moriwaki K, Suzuki H.
ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner. Hum Mol Genet. (2011).(22156770)
Kohama C, Kato H, Numata K, Hirose M, Takemasa T, Ogura A, Kiyosawa H.
Efficient Production of Offspring from Japanese Wild-Derived Strains of Mice (Mus musculus molossinus) by Improved Assisted Reproductive Technologies. Biol Reprod. (2012).(22337332)
Hasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A.
Large, Male Germ Cell-Specific Hypomethylated DNA Domains With Unique Genomic and Epigenomic Features on the Mouse X Chromosome. DNA Res. (2013).(23861320)
Ikeda R, Shiura H, Numata K, Sugimoto M, Kondo M, Mise N, Suzuki M, Greally JM, Abe K.
Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus. PLoS One.9(12) e114305: e114305 (2014).(25470728)
Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Sci Rep7: 42476 (2017).(28195201)
Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A.
Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation. Nature548(7666): 224-227 (2017).(28746308)
Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y.