RBRC00222, SL/Kh

RBRC No. RBRC00222
Type Inbred
Species Mus musculus
Strain name SL/Kh
Former Common name No Data
H-2 Haplotype No Data
Background strain SL/KhStm
1 Appearance albino
Genotype A/A, B/B, c/c
Strain development The spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.
Strain description SL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model.
Colony maintenance Sibling Mating
High incidence of pre-B lymphomas at early age
Health Report
Gene Details
Promoter No Data
1 Symbol Bomb1
Symbol name bone marrow pre-B 1
Chromosome 3
Common name No Data
Symbol description No Data
2 Symbol Tlsm1
Symbol name thymic lymphoma susceptible 1
Chromosome 7
Common name No Data
Symbol description No Data
References Cancer Res. 1994 Jan 15;54(2):399-402.
Cancer Res. 1994 Jan 15;54(2):403-7.
Cancer Res. 1996 Aug 15;56(16):3716-20.
Cancer Res. 1999 Jun 1;59(11):2593-5.
J Exp Med. 1994 Dec 1;180(6):2155-62.
J Natl Cancer Inst. 1987 Oct;79(4):781-7.
Lab Anim Sci. 1996 Aug;46(4):410-7.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8253-8. Epub 2002 Jun 4.

Research applications Cancer Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proc. Natl. Acad. Sci. USA99: 8253-8258 (2002).(12048235)
Tatsuaki TSURUYAMA, Takuro NAKAMURA, Guang JIN, Munetaka OZEKI, Yoshihiro YAMADA, Hiroshi HIAI
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood100: 238-245 (2002).(12070033)
Scott C KOGAN, Jerrold M WARD, Miriam R ANVER, Jules J BERMAN, Cory BRAYTON, Robert D CARDIFF, John S CARTER, Sherri de CORONADO, James R DOWNING, Torgny N FREDRICKSON, Diana C HAINES, Alan W HARRIS, Nancy Lee HARRIS, Hiroshi HIAI, Elaine S JAFFE, Ian C M MACLENNAN, Pier Paolo PANDOLFI, Paul K PATTENGALE, Archibald S PERKINS, R Mark SIMPSON, Mark S TUTTLE, Joanne F WONG, Herbert C 3rd MORSE
Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas. Cancer Sci.94: 791-795 (2003).(12967477)
Guang JIN, Tatsuaki TSURUYAMA, Yoshihiro YAMADA, Hiroshi HIAI
Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis. Leuk Res.32(2): 309-14 (2008).(17617450)
Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S, Springer-Verlag. Springer-Verlag227-244 (2008).
Hiai H.
In vitro murine leukemia retroviral integration and structure fluctuation of target DNA. PLoS One.7(2): e31533 (2012).(22348097)
Tsuruyama T, Liu W, Yoshikawa K.
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene (2015).(26522721)
Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. J. Cell Biochem. (2016).(27018255)
Tsuruyama T, Hiratsuka T, Wulamujiang A, Nakamura T.
DNA insertion mutations can be predicted by a periodic probability function. arXiv (2017).
Tatsuaki Tsuruyama.