RBRC00300, B6.129S6-Rela<tm1Yuo>/1Rbrc

RBRC No. RBRC00300
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S6-Rela<tm1Yuo>/1Rbrc
Former Common name RelA KO, RKO-1
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Donor strain 129S6/SvEvTac via EK.CCE ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Rela
Symbol name v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Chromosome 19
Common name p65 NFkB, p65 NF-kappa B, avian reticuloendotheliosis viral (v-rel) oncogene homolog A
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 19
Common name neo; neomycin;
Symbol description No Data
References J Exp Med. 1997 Mar 3;185(5):953-61.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2994-9.

Research applications Cell Biology Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J Exp Med., 185, 953-961 (1997).
Any patent rights and other intellectual properties are retained by the depositor. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Doi, Takahiro (RIKEN, BioResource Center) Doi, Takahiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription. J Immunol.179(10): 6596-603 (2007).(17982049)
Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS.
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol.10(5): 611-8 (2008).(18391940)
Kawauchi K, Araki K, Tobiume K, Tanaka N.