RBRC00379, B6.Cg-Hm+/+Reln<rl>/NemOdaRbrc

RBRC No. RBRC00379
Type Spontaneous Mutation wks
Species Mus musculus
Strain name B6.Cg-Hm+/+Reln<rl>/NemOdaRbrc
Former Common name C57BL/6-Hm/+-rl/+
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Sen-ichi Oda, Nagoya University. This strain was generated by crossbreeding heterozygotic reeler (C57BL/6-rl) and hammer-toe (C57BL/6-Hm) mutants.
Strain description B6.Cg-Hm+/+Reln<rl>. This strain was generated by crossbreeding heterozygotic reeler (Reln<rl>) and hammer-toe (Hm) mutant mice to facilitate distinguishing between heterozygous reeler mice (rl/+) and wildtype. The Hammer-toe semidominant gene is located near reeler locus on the homologous chromosome. The reeler mutation causes an abnormal pattern in the layering of neurons in the neocortex and the cerebellum. The reeler homozygous (rl/rl) mutant mice show impaired motor coordination, tremors and ataxia. The hammer-toe homozygous (Hm/Hm) mutant mice show markedly-flexed digits having a fusion of the interdigital tissues, whereas in Hm heterozygotes (Hm/+) the degree of flexion is not so severe compared to those of homozygotes.
Colony maintenance Sibling mating (Hm +/+ rl x Hm +/+ rl)
Reeler homozygous mutant mice show impaired motor coordination, tremors and ataxia, and die by 4 weeks of age. Hammer toe homozygous mutant mice are viable and fertile.
Health Report
Gene Details
Promoter No Data
1 Symbol Hm
Symbol name hammer toe
Chromosome 5
Common name No Data
Symbol description No Data
2 Symbol Reln
Symbol name reelin
Chromosome 5
Common name No Data
Symbol description No Data
References Anat Embryol (Berl). 1993 Oct;188(4):317-29.

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months