RBRC00388, PROD-Cacna1a<tg-rol>/NemOdaRbrc

RBRC No. RBRC00388
Type Spontaneous Mutation wks
Species Mus musculus
Strain name PROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common name PROD-rol/+
H-2 Haplotype No Data
Background strain No Data
1 Appearance agouti with white spot
Genotype A/A B/? C/C s/s
Strain development Developed by Dr. Sen-ichi Oda, Nagoya University. Cacna1a<tg-rol> arose spontaneously in descendants of (SIII x C57BL/6)F1 in 1969.
Strain description Rolling mouse Nagoya, PROD-Cacna1a<tg-rol>/NemOdaRbrc. Cacna1a gene is a voltage-gated pore-forming membrane protein, mediates Ca2+ influx across presynaptic and somatodendritic membranes, thereby triggering fast neurotransmitter release and other key neuronal responses. Homozygous mutant mice exhibit a severe ataxia, episodic dyskinesia, and cerebellar atrophy.
Colony maintenance Homozygous mutant mice are identifiable between 10 and 14 days old by a creeping or rolling gait.
homozygous females are fertile but do not breed well.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Cacna1a
Symbol name calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Chromosome 8
Common name alpha1A, Cacnl1a4, Ccha1a, EA2, MHP1, nmf352, SCA6
Symbol description No Data
References Biomed. Res., 1, 88-90 (1980).
Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982).
Jpn. J. Genet., 56, 295-299 (1981).
Dev Psychobiol. 1986 Jan;19(1):67-77.
J Neurosci. 2000 Aug 1;20(15):5654-62.
Neurosci Lett. 1999 Apr 30;266(1):49-52.
Neurosci Res. 1988 Apr;5(4):316-24.

Research applications Developmental Biology Research,
Genetics Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood.107(3): 1078-84 (2006).(16219795)
Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya. Exp Gerontol.44(4): 274-9 (2009).(19073246)
Takahashi E, Niimi K.
Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neuroscience.160(1): 165-73 (2009).(19248821)
Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice. Brain Res.1279 16983: (2009).(19446536)
Takahashi E, Niimi K, Itakura C.
Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res.204(1): 241-5 (2009).(19467269)
Takahashi E, Niimi K, Itakura C.
Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya. J Mol Neurosci.41(2): 223-9 (2010).(19609731)
Takahashi E, Niimi K, Itakura C.
Ca(2+) channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca(2+) channel mutant mouse, rolling mouse Nagoya. Neurosci Res.73(3): 199-206 (2012).(22575052)
Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Analysis of ischemic neuronal injury in Cav2.1 channel alpha 1 subunit mutant mice. Biochem Biophys Res Commun. (2013).(23545255)
Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction. Behav Brain Res. (2013).(24177210)
Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury. Brain Res. (2016).(27840189)
Kim TY, Niimi K, Takahashi E.