RBRC00407, B6.129P2-Tcrd<tm1Mom>/ItoRbrc

RBRC No. RBRC00407
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Tcrd<tm1Mom>/ItoRbrc
Former Common name TCR delta-KO, TCRd KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Donor strain 129P2/OlaHsd via E14 ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Strain description Developed by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Colony maintenance Sibling Mating
Homozygous mutant mice are viable and fertile.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Tcrd
Symbol name T-cell receptor delta chain
Chromosome 14
Common name Tcr delta, Tcrdelta
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References Cell. 1993 Feb 12;72(3):337-48.

T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.
Research applications Cell Biology Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Itohara et al., Cell, 72, 337-348 (1993).
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Itohara, ShigeYoshi (RIKEN Center for Brain Science) Itohara, ShigeYoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Involvement of NK1.1+ {gamma}{delta}T Cells in the IL-18 Plus IL-2-Induced Interstitial Lung Disease. Am J Respir Cell Mol Biol. (2011).(21257923)
Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T.
The regulatory role of IFN-γ producing gammadelta T cells via the suppression of Th17 cell activity in bleomycin-induced pulmonary fibrosis. Clin. Exp. Immunol. (2016).(27083148)
Segawa S, Goto D, Iizuka A, Kaneko S, Yokosawa M, Kondo Y, Matsumoto I, Sumida T.