RBRC00422, C.Cg-Cpox<nct>/JmsRbrc

RBRC No. RBRC00422
Type Spontaneous Mutation wks
Species Mus musculus
Strain name C.Cg-Cpox<nct>/JmsRbrc
Former Common name NCT, BALB/c-nct/nct
H-2 Haplotype No Data
Background strain No Data
1 Appearance albino
Genotype A/A b/b c/c
Strain development Cataract mutation arose spontaneously in the multiple breeding colony. The mutant mice were backcrossed to BALB/c (1988).
Strain description Nakano cataract mice, spontaneous recessive mutant. Homozygous mutant mice develop cataracts. A spontaneous G to T transversion was occurred in the Cpox gene, resulting in the amino acid substitution of Leu for Arg at position 380.
Colony maintenance Sibling Mating (Homozyogote x Homozygote)
Health Report
Gene Details
Promoter No Data
1 Symbol Cpox
Symbol name coproporphyrinogen oxidase
Chromosome 16
Common name No Data
Symbol description No Data
References Exp Eye Res. 2002 Dec;75(6):745-51.
Genomics. 1998 May 15;50(1):119-20.

Research applications Sensorineural Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Hiai, Hiroshi (Kyoto University) Hiai, Hiroshi
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
Genetic Analysis of Nakano Cataract and Its Modifier Genes in Mice Exp. Eye. Res.75: 745-751 (2002).(12470976)
Makiko NARITA, Yun WANG, Akiyo KITA, Natsue OMI, Yoshihiro YAMADA, Hiroshi HIAI
Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Exp Eye Res. (2013).(23631845)
Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K.
A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice. Exp. Anim.64(2): 171-9 (2015).(25736709)
Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M.