RBRC00688, B6;129S-Psap<tm2Suz>/JumaRbrc

RBRC No. RBRC00688
Type Targeted MutationCartagena 6wks,♂
Species Mus musculus
Strain name B6;129S-Psap<tm2Suz>/JumaRbrc
Former Common name mouse saposin A mutant mouse
H-2 Haplotype No Data
Donor strain 129/SvEv
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype No Data
2 Appearance brown
Genotype No Data
Strain development 2001, Junko Matsuda, M.D. and Kunihiko Suzuki, M.D.
Neuroscience Center, Departments of neurology and Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7250, U.S.A.
Strain description Neurobiology Research, Metabolic Defects, Lysosomal Disease, Demyelinating disease
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Psap
Symbol name prosaposin
Chromosome 10
Common name SGP-1, saposin A
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
References Hum Mol Genet. 2001 May 15;10(11):1191-9.
Hum Mol Genet. 2001 Nov 1;10(23):2709-15.

A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse.
A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse.
Research applications Cre/loxP system,
Metabolism Research,
Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Matsuda, Junko (The University of Tokushima) Matsuda, Junko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months