RBRC00753, B6;129P2-Sema4d<tm1Kik>/Rbrc

RBRC No. RBRC00753
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Sema4d<tm1Kik>/Rbrc
Former Common name CD100 Knockout mice
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sema4d
Symbol name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Chromosome 13
Common name CD100, coll-4, M-sema G, Semacl2, SEMAJ, Semaj, semaphorin H, Semcl2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References Immunity. 2000 Nov;13(5):633-42.

The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity, 13, 633-642 (2000).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Kikutani, Hitoshi (Osaka university) Kikutani, Hitoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Sema4D is required in both the adaptive and innate immune responses of contact hypersensitivity. Mol Immunol.78: 98-104 (2016).(27614265)
Zhu Z, Luo Y, Yu J, Gao J, Zhang Y, Xiao C, Zhang C, Wang G, Liu Y, Fu M, Yao X, Li W.