RBRC00754, B6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc

RBRC No. RBRC00754
Type Targeted Mutation and TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc
Former Common name CD40 transgenic mice
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hitoshi Kikutani, Research Institute for Microbial Diseases, Osaka University in 2002.
Strain description Transgenic mice expressing wild-type human CD40 gene in a mouse CD40 deficient background. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Tnfrsf5
Symbol name tumor necrosis factor receptor superfamily, member 5
Chromosome 2
Common name Bp50, Cd40, IGM, p50
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
Promoter mouse E m, IgH promoter, rabbit beta-globin poly A
3 Symbol TNFRSF5
Symbol name tumor necrosis factor receptor superfamily, member 5 (human)
Chromosome UN
Common name Bp50, Cd40, IGM, p50
Symbol description No Data
References Int Immunol. 2002 Mar;14(3):319-29.
Nature. 1985 Jul 4-10;316(6023):67-9.

Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Inter. Immunol., 14, 319-329 (2002).
Additional information
1 No Data
Depositor Kikutani, Hitoshi (Osaka university) Kikutani, Hitoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months