Strain Information | |
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Image | |
BRC No. | RBRC00754 |
Type | Targeted Mutation and Transgene |
Species | Mus musculus |
Strain name | B6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc |
Former Common name | CD40 transgenic mice |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Hitoshi Kikutani, Research Institute for Microbial Diseases, Osaka University in 2002. |
Strain description | Transgenic mice expressing wild-type human CD40 gene in a mouse CD40 deficient background. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation. |
Colony maintenance | |
References | Nature, 316, 67-69 (1985). 2409451 Int. Immunol., 14, 319-329 (2002). 11867568 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
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Donor DNA | mouse Em, IgH promoter, human CD40 cDNA, rabbit beta-globin poly A, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse CD40 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Inter. Immunol., 14, 319-329 (2002). |
Depositor | Hitoshi Kikutani (Osaka University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |