RBRC00762, C;B6-a/a-b/b-W Sh /W Sh

RBRC No. RBRC00762
Type Spontaneous Mutation 4wks
Species Mus musculus
Strain name C;B6-a/a-b/b-WSh/WSh
Former Common name W Sash Brown
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance white coat with black eyes
Genotype a/a b/b C/C sh/sh
Strain development C57BL/6-Kit<W-sh> mice were deposited by Dr. Yukihiko Kitamuta, Osaka University to the RIKEN BRC. The mice were backcrossed to BALB/c for several generation, then maintained by sister-brother mating as homozygous state.
Strain description The Kit<W-sh> mutation arose spontaneously in the (C3H/HeN x 101/H)F1 at the MRC (Lyon et al., 1982). Homozygous mice are white coat with black eyes. Heterozygotes are black with a white sash. This strain is useful for study of melanogenesis and neural crest migration.
Colony maintenance Sibling mating (Homozygote x Homozygote)
Homozygous mutant mice are viable and fertile.
Health Report
Gene Details
Promoter No Data
1 Symbol Kit
Symbol name kit oncogene
Chromosome 5
Common name No Data
Symbol description No Data
References Am J Pathol. 2005 Sep;167(3):835-48.
Blood. 1992 Sep 15;80(6):1448-53.
Blood. 1994 Jun 15;83(12):3509-16.
Blood. 1999 Oct 15;94(8):2658-66.
Development. 1993 Jul;118(3):705-17.

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Research applications Reproductive Biology Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 Genetic Background
2 Genotyping protocol <PCR>
Depositor RIKEN, BioResource Center
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
W(sh)/W(sh) c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine. Neurosci Lett.459(3): 123-6 (2009).(19427361)
Iino S, Horiguchi K, Nojyo Y.