RBRC00765, INAD

RBRC No. RBRC00765
Type Spontaneous Mutation
Species Mus musculus
Strain name INAD
Former Common name infantile neuroaxonal dystrophy: INAD
H-2 Haplotype No Data
Background strain C57BL/6
Appearance
1 Appearance black
Genotype (a/a B/B C/C)
Strain development Discovered in a C57BL/6 breeding colony. Developed by Dr. Yoshibumi Matsushima, Saitama Cancer Center in 2005.
Strain description The spontaneous mutation that was discovered in a C57BL/6 breeding colony. Homozygous mutant mice exhibit the incoordinated limbs and lean body in the lower half of the body, and die from 4 to 5 weeks after birth. In these mice, a neurodystrophic change appearing as spheroid bodies in central and peripheral nervous system is observed. This strain is useful as a mouse model for infantile neuroaxonal dystrophy (INAD).
Colony maintenance Sibling Mating (Heterozygote x Heterozygote) or Transplant-Cross-Intercross (maintenace by ovary transplantation, Homozygote x Heterozygote)
Homozygous mutant mice die before sexual maturity.
Health Report
Gene Details
Promoter No Data
1 Symbol inad
Symbol name infantile neuroaxonal dystrophy
Chromosome 1
Common name infantile neuroaxonal dystrophy
Symbol description No Data
References Mamm Genome. 2005 Feb;16(2):73-8.

A new mouse model for infantile neuroaxonal dystrophy, inad mouse, maps to mouse chromosome 1.
Research applications Mouse Models for Human Disease
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 Mouse of the Month Mar 2005
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months