RBRC00804, B6.129P2-S100b<tm1Ito>/ItoRbrc

RBRC No. RBRC00804
Type Targeted Mutation CongenicCartagena 8wks,♂
Species Mus musculus
Strain name B6.129P2-S100b<tm1Ito>/ItoRbrc
Former Common name S100b-KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Donor strain 129P2/OlaHsd via E14 ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed Hiroshi Nishiyama and Shigeyoshi Itohara, Brain Science Institute, RIKEN. E14 ES cells were used. The mutant mice were backcrossed to C57BL/6.
Strain description S100b gene knockout mice. Exon 2 and part of exon 3 of S100b gene were replaced with a floxed neo cassette. Homozygous mutant mice are viable and fertile.
Colony maintenance Sibling Mating
Health Report
Gene Details
Promoter No Data
1 Symbol S100b
Symbol name calcium-binding protein S100b
Chromosome 10
Common name Bpb
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data
References Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4037-42. Epub 2002 Mar 12.

Glial protein S100B modulates long-term neuronal synaptic plasticity.
Research applications Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 99, 4037-4042 (2002).
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Itohara, ShigeYoshi (RIKEN Center for Brain Science) Itohara, ShigeYoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
S100B transgenic mice develop features of Parkinson’s disease. Arch Med Res.42(1): 40549 (2011).(21376255)
Liu J, Wang H, Zhang L, Xu Y, Deng W, Zhu H, Qin C.