RBRC00872, XO

RBRC No. RBRC00872
Type Chromosomal Aberration
Species Mus musculus
Strain name XO
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance agouti with tabby
Genotype X/X, X/Y
2 Appearance agouti with mosaic striped coat
Genotype X/X
Strain development Deposited by Dr. Nobuo Takagi, Hokkaido University.
Strain description Strain with monosomic X choromosomal aberration (X/O). This strain also has tabby (Eda<Ta>) mutation that affects both the coat color and hair pattern growth. The mice having X<Ta>/O or X<Ta>/Y show yellow coat, no hair on ears and tail, bald patch behind ears, and no guard hairs. Meanwhile, X<Ta>/X females show agouti with mosaic striped due to X-inactivation.
agouti with tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs) (X<Ta>/X<Ta>, X<Ta>/Y); agouti with mosaic striped coat (X<Ta>/X)
Colony maintenance This strain is maintained using tabby as a phenotypic marker to keep monosomic X chromosome condition. When wild-type female (X/O) is bred to hemizygote tabby male (X<Ta>/Y) in the first generation, hemizygote tabby female (X<Ta>/O) is bred to wild-type male (X/Y) in the second generation. On the contrary, when hemizygote tabby female (X<Ta>/O) is bred to wild-type male (X/Y) in the first generation, wild-type female (X/O) is bred to hemizygote male (X<Ta>/Y) in the second generation.
Health Report
Gene Details
Promoter No Data
1 Symbol Eda
Symbol name ectodysplasin-A
Chromosome X
Common name Ed1, Eda-A1, Eda-A2, EDA1
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Takagi, Nobuo (Hokkaido University) Takagi, Nobuo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Defects in the first wave of folliculogenesis in mouse XO ovaries. J. Reprod. Dev.63(3): 333-338 (2017).(28392504)
Miura K, Murata C, Harikae K, Suzuki H, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y.