RBRC00915, C.Cg-Irf9<tm1Ttg>/TtgRbrc

RBRC No. RBRC00915
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name C.Cg-Irf9<tm1Ttg>/TtgRbrc
Former Common name IRF-9 KO/BALB/c; BALB/cAJcl-Isgf3g<tm1>, IRF-9 Knockout mouse, BALB/c
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 EC cell line
Background strain BALB/cAJcl
Appearance
1 Appearance albino
Genotype No Data
Strain development Developed by Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo. RBRC00915: Backcrossed to BALB/c (N8 generations), RBRC00916: Backcrossed to C57BL/6J (over N13 generations).
Strain description IRF-9 gene knockout mice. Homozygous mutant mice exhibit lower serum interferon levels in response to viral infection. BALB/c background (RBRC00915), C57BL/6 background (RBRC00916).
Colony maintenance Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol Irf9
Symbol name interferon regulatory factor 9
Chromosome 14
Common name Irf-9, p48, Isgf3g
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References Genes Cells. 1996 Jan;1(1):115-24.

Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT shall inform the DEPOSITOR about the purpose of the use of the BIOLOGICAL RESOURCE and shall limit the use within the scope of the purpose described in this Agreement. The RECIPIENT shall inform the DEPOSITOR about the results obtained by the use of the BIOLOGICAL RESOURCE.
Additional information
1 Mouse of the Month May 2005
2 Taniguchi Lab HP
3 Genotyping protocol <PCR>
Depositor Taniguchi, Tadatsugu (The University of Tokyo, Graduate School of Medicine) Taniguchi, Tadatsugu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest.118(4): 1417-26 (2008).(18340381)
Thibault DL, Chu AD, Graham KL, Balboni I, Lee LY, Kohlmoos C, Landrigan A, Higgins JP, Tibshirani R, Utz PJ.
Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat. Commun. (2015).(25953241)
Martinet V1, Tonon S1, Torres D1, Azouz A1, Nguyen M1, Kohler A1, Flamand V1, Mao CA2, Klein WH2, Leo O1, Goriely S1.