RBRC00993, B6.129S4-Sh2b3<tm1Rmp>/Rbrc

RBRC No. RBRC00993
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S4-Sh2b3<tm1Rmp>/Rbrc
Former Common name C57BL/6 Lnk -/-
H-2 Haplotype No Data
ES cell line AK7 [129S4/SvJaeSor]
Donor strain 129S4/SvJaeSor via AK7 ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sh2b3
Symbol name SH2B adapot protein 3
Chromosome 5
Common name Lnk; linker of T-cell receptor pathways
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
References Immunity. 2000 Nov;13(5):599-609.
Nat Genet. 2001 Mar;27(3):293-8.

Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins.
Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity 13, 599-609 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in the articles when the users publish their data using these mice for 1 year after provided.
Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Takagi, Satoshi (National Center for Global Health and Medicine) Takagi, Satoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3. Hypertension (2015).(26101343)
Zhu X, Fang J, Jiang DS, Zhang P, Zhao GN, Zhu X, Yang L, Wei X, Li H.