RBRC01102, B6.Cg-Tg(Camk2a-Fyn)1Kndl/Rbrc

RBRC No. RBRC01102
Type Transgene CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Tg(Camk2a-Fyn)1Kndl/Rbrc
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Nobuhiko Kojima, National Institute for Physiological Sciences, Japan at 1994. The FynB fragment including the CaMKII alpha promoter was injected into the pronuclei of B6CBF1 fertilized egges. The transgenic mice were backcross to C57BL/6J mice for 25 generations.
Generation:N23+N2
Strain description B6.Cg-Tg(Camk2a-Fyn)1Kndl/Rbrc. Transgenic mice overexpressing native Fyn under the control of the calcium/calmodulin-dependent protein kinase II alpha promoter. The transgenic Fyn is more expressed at high levels in the neurons of the adult forebrain than the neonatal one. The transgenic mice exhibit no obvious epileptic behavior, but the kindling of these mice is accelerated by once-daily stimulation of the amygdala. This strain is useful for elucidation of the role of Fyn tyrosine kinase in synaptic plasticity.
Colony maintenance Backcross to C57BL/6 (Hemizygote x C57BL/6JJcl)
Reproductive performance is good.
Health Report No Data
Gene Details
Promoter mouse Camk2a promoter
1 Symbol Fyn
Symbol name Fyn proto-oncogene
Chromosome UN
Common name No Data
Symbol description No Data
References Learn Mem. 1998 Nov-Dec;5(6):429-45.

Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice.
Research applications Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Learning and Memory, 5, 429-445 (1998).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Kojima, Nobuhiko (RIKEN Center for Brain Science) Kojima, Nobuhiko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months