RBRC01151, hairy and enhancer of split-related 1

RBRC No. RBRC01151
Type Targeted MutationCartagena
Species Mus musculus
Strain name hairy and enhancer of split-related 1
Former Common name hesr1, hairy and enhancer of split-related 1
H-2 Haplotype No Data
ES cell line AB1 [129S7/SvEvBrd-Hprt<+>]
Donor strain 129S7/SvEvBrd via AB1 ES cell line
Background strain C57BL/6NJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. H. Kokubo and R.L. Johnson at University of Texas M.D. Anderson Cancer Center in 1999. A loxP-flanked neo cassette was transferred into AB1 ES cells to replace the bHLH region, from exon 1 to exon 4. C57BL/6 and 129 mixed background.
Strain description B6;129S7-Hey1<tm1Kkb>. Hey1 gene is a member of the hairy and enhancer of split related family of bHLH transcription factors, play a important roles in mediating Notch signaling in the developing cardiac and vascular systems.
Colony maintenance Sibling Mating
Homozygous mutant mice are viable and fertile.
Health Report
Gene Details
Promoter No Data
1 Symbol Hey1
Symbol name hairy and enhancer of split-related 1
Chromosome 3
Common name Hairy/E(spl)-related with YRPW motif 1, Herp2, hesr-1, HRT1
Symbol description No Data
2 Symbol IRES
Symbol name internal ribosomal entry site (EMCV)
Chromosome 3
Common name internal ribosomal entry site from EMCV
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 3
Common name No Data
Symbol description E. coli beta galactosidase
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome 3
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 3
Common name neo; neomycin;
Symbol description No Data
References

Research applications Cell Biology Research,
Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 Saga Lab HP
2 Genotyping protocol <PCR>
Depositor Saga, Yumiko (National Institute of Genetics) Saga, Yumiko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months