| RBRC No. | RBRC01154 |
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|---|---|---|---|---|---|---|---|---|---|
| Type | Transgene |
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| Species | Mus musculus | ||||||||
| Strain name | B6.Cg-Tg(Six3-cre)69Frty | ||||||||
| Former Common name | TgN(Six3 Cre)69Frt; Six3Cre#69 | ||||||||
| H-2 Haplotype | No Data | ||||||||
| Background strain | No Data | ||||||||
| Appearance | |||||||||
| 1 | Appearance | black | |||||||
| Genotype | a/a B/B C/C | ||||||||
| Strain development | Developed by Yasuhide Furuta, University of Texas, M.D. Anderson Cancer Center. The Six3-cre transgene fragment was injected into the pronuclei of B6D2F2 fertilized eggs. The mice were crossed to C57BL/6 (N5 times). | ||||||||
| Strain description | Transgenic mice expressing Cre recombinase in a central region of the developing retina and widely in the ventral forebrain. Useful for tissue-specific gene activation/inactivation approaches. In particular, consequences of gene activation/inactivation in Cre-expressing cells within the retina can be assessed in direct comparisons to the surrounding non-Cre-expressing cells in an animal. Line 69 (RBRC01154), Line 22 (RBRC01153). | ||||||||
| Colony maintenance | Carrier x Carrier | ||||||||
| Health Report | No Data | ||||||||
| Gene Details | |||||||||
| Promoter | No Data | ||||||||
| 1 | Symbol | GH | |||||||
| Symbol name | Growth hormone polyA (Bovine) | ||||||||
| Chromosome | UN | ||||||||
| Common name | No Data | ||||||||
| Symbol description | No Data | ||||||||
| 2 | Symbol | nls | |||||||
| Symbol name | SV40 large T antigen nuclear localization signal (NLS) | ||||||||
| Chromosome | UN | ||||||||
| Common name | No Data | ||||||||
| Symbol description | No Data | ||||||||
| Promoter | mouse Six3 promoter | ||||||||
| 3 | Symbol | cre | |||||||
| Symbol name | Phage P1 Cre recombinase | ||||||||
| Chromosome | UN | ||||||||
| Common name | No Data | ||||||||
| Symbol description | No Data | ||||||||
| References | Genesis. 2000 Feb;26(2):130-2.
Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice.
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| Research applications | Cell Biology Research, Cre/loxP system, Genetics Research |
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| Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 26, 130-132 (2000). |
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| Additional information | |||||||||
| 1 | Mouse of the Month June 2006 | ||||||||
| 2 | Genotyping protocol <PCR> | ||||||||
| Depositor | Furuta, Yasuhide (University of Texas, M.D. Anderson Cancer Center)  |
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| Strain Status / Availability (Expected delivery) |
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