RBRC01188, B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak/TanakRbrc

RBRC No. RBRC01188
Type TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak/TanakRbrc
Former Common name t(7;11)AML NUP98-HOXA9 transgenic (Tg) mice
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Kakuro Nakamura, NIH in 1996. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J over 10 times.
Strain description B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak. This transgenic mice express the chimeric NUP98-HOXA9 gene in the myeloid lineage. About 20% of mice with this transgene exhibit myeloproliferative disorder and acute myeloid leukemia (AML).
Colony maintenance Carrier x Noncarrier [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol CTSG
Symbol name Cathepsin G (human)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol HOXA9
Symbol name homeo box A9 (human)
Chromosome UN
Common name No Data
Symbol description No Data
Promoter human Cathepsin G promoter
3 Symbol NUP98
Symbol name nucleoporin 98 (human)
Chromosome UN
Common name No Data
Symbol description No Data
References Blood 2005 Jan 15;105(2):784-93. Epub 2004 Sep 28.

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.
Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 The Cancer Institute of JFCR
2 Mouse of the Month Mar 2006
3 Genotyping protocol <PCR>
Depositor Nakamura, Takuro (Japanese Foundation for Cancer Research) Nakamura, Takuro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis. Cell Cycle.10(9): 1456-67 (2011).(21467841)
Funasaka T, Nakano H, Wu Y, Hashizume C, Gu L, Nakamura T, Wang W, Zhou P, Moore MA, Sato H, Wong RW.