RBRC01190, 129-Bcl11a<tm1Ngc>/Rbrc

RBRC No. RBRC01190
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name 129-Bcl11a<tm1Ngc>/Rbrc
Former Common name Evi9/BclIIa Knockout mice
H-2 Haplotype No Data
ES cell line CJ7 [129/SvlmJ]
Donor strain 129S1/SvImJ via CJ7 ES cell line
Background strain No Data
Appearance
1 Appearance white-bellied agouti
Genotype A/A B/B C/C
Strain development Developed by Drs. Pentao Liu and Neal G Copeland at NIH in 1999. A PGK-neo cassette replaced was transfered into CJ7 ES cells to replace exon 1 of Bcl11a gene.
Strain description Developed by Drs. Pentao Liu and Neal G Copeland at NIH in 1999. A PGK-neo cassette replaced was transfered into CJ7 ES cells to replace exon 1 of Bcl11a gene.
Colony maintenance Sibling Mating (Heterozygote x Wild-type, Heterozygote)
Homozygous mutant mice die within 3-4hrs after birth.
Health Report
Gene Details
Promoter No Data
1 Symbol Bcl11a
Symbol name B-cell CLL/lymphoma 11A (zinc finger protein)
Chromosome 11
Common name 2810047E18Rik, 4930538E20Rik, COUP-TF interacting protein 1, CTIP1, Evi9, mKIAA1809, mouse myeloid leukemia gene
Symbol description No Data
2 Symbol GH
Symbol name Growth hormone polyA (Bovine)
Chromosome 11
Common name No Data
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 11
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
References Nat Immunol. 2003 Jun;4(6):525-32. Epub 2003 Apr 28.

Bcl11a is essential for normal lymphoid development.
Research applications Fluorescent Proteins/lacZ System,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Immunol., 6, 525-532 (2003).
Additional information
1 The Cancer Institute of JFCR
2 Genotyping protocol <PCR>
Depositor Nakamura, Takuro (Japanese Foundation for Cancer Research) Nakamura, Takuro
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months