Strain Information | |
---|---|
Image | |
BRC No. | RBRC01195 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.129S6-Grin2a<tm1Nak>/NakRbrc |
Former Common name | NR2A KO, C57BL/6J-Grin2a tm |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C)] |
Strain development | Developed by Drs. H. Kadotani and S. Nakanishi, Kyoto University in 1996. |
Strain description | B6.129S6-Grin2a<tm1Nak>. The Grin2a gene is one of the glutamate receptor channel subunit families forming NMDA receptor channel, which is important for synaptic plasticity. Homozygous mutant mice are viable and fertile. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6J) |
References | J. Neurosci., 16, 7859-7867 (1996). 8987814 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)16Grin2a<tm1Nak>targeted mutation 1, Shigetada Nakanishi Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)16neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
---|---|
Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse NMDA receptor NR2A subunit genomic DNA |
Research application | Neurobiology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Journal of Neuroscience, 16, 7859-7867 (1996).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Shigetada Nakanishi (Kyoto University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
Lu Y, Mu L, Elstrott J, Fu C, Sun C, Su T, Ma X, Yan J, Jiang H, Hanson JE, Geng Y, Chen Y. Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice. EBioMedicine 102 105045(2024) 38471394 Gao X, Qiao Y, Jia B, Jing X, Cheng B, Wen L, Tan Q, Zhou Y, Zhu B, Qiao H. NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36. Evid Based Complement Alternat Med 2012 438460(2012) 23118791 Su T, Lu Y, Fu C, Geng Y, Chen Y. GluN2A mediates ketamine-induced rapid antidepressant-like responses. Nat Neurosci (2023) 37709995 |