RBRC01229, B6;129-Foxh1<tm1.1Hmd>/HmdRbrc

RBRC No. RBRC01229
Type Targeted Mutation and Chromosomal Aberration and F2 HybridCartagena
Species Mus musculus
Strain name B6;129-Foxh1<tm1.1Hmd>/HmdRbrc
Former Common name B6;129-FoxH1+/-, FAST+/-, B6;129-FoxH1tm1Hh(B6;129-FoxH1+/-,FAST+/- ) knockout mice
H-2 Haplotype No Data
Donor strain (129X1/SvJ x 129S1/Sv)F1-Kitl+ via R1 ES cell line
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Masamichi Yamamoto and Hiroshi Hamada at Osaka University in 2001. Foxh1<tm1.1Hmd> mutant mice were generated from Foxh1<tm1Hmd> mutant mice by crossing with cre-expressing line, Tg(ACTB-cre)Miya mice strain.
Strain description B6;129-Foxh1<tm1.1Hmd>. The transcription factor Foxh1 (horkhead box H1) mediates signaling by transforming growth factor-β, Activin, and Nodal. Foxh1 null deficient mice are perinatal lethal. The embryos of Foxh1 deficient mice exhibit various patterning defects by the loss of Nodal signaling. This mice are useful for the study of Foxh1 gene in vivo.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6Cr)
Homozygous mutant mice are perinatal lethal.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol FoxH1
Symbol name forkhead box H1
Chromosome 15
Common name FAST
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 15
Common name No Data
Symbol description No Data
References Genes Dev. 2001 May 15;15(10):1242-56.

The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse.
Research applications Developmental Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on
use of it from the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Hamada, Hiroshi (RIKEN Center for Developmental Biology) Hamada, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months