|Former Common name||Black-eyed white, Mitf<mi-bw> mutant mouse|
|H-2 Haplotype||No Data|
|Background strain||No Data|
|1||Appearance||black eyed white|
|Genotype||A/A B/B C/C mi
|Strain development||The original mutant strain, C3HBSt carrying Mitf<mi-bw> allele was provided by Dr. Walter C. Quevedo Jr., Brown University to Tohoku University. The originals were backcrossed to C57BL/6J strain for 13 times. After several years, they were backcrossed to C3H/He strain because the homozygous mice became difficult to breed.|
|Strain description||C3;B6-Mitf<mi-bw>. The Mitf, microphthalmia-associated transcription factor plays a critical role in the development of melanocytes, mast cells, osteoclasts and pigmented epithelium. Homozygous mice for the Mitf<mi-bw> mutation display a white coat with black eyes. In this allele, a L1 element was inserted into intron 3. This strain is useful as an animal model for Waardenburg syndrome type 2 (WS2)|
|Colony maintenance||Sibling Mating (Homozygote x Homozygote)
Homozygote shows white coat color with black eyes.
|Symbol name||microphthalmia-associated transcription factor|
|Common name||black eyed white, mi, wh|
|Symbol description||No Data|
|References||Hum Mol Genet. 1999 Aug;8(8):1431-41.
An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness.
|Research applications||Genetics Research,
Mouse Models for Human Disease
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Hum. Mol. Genet., 8, 1431-1441 (1999).
|1||Mouse of the Month Dec 2006|
|Depositor||Yamamoto, Hiroaki (Nagahama Institute of Bio-Science and Techology)|
|Strain Status /
|Microphthalmia-associated transcription factor is expressed in projection neurons of the mouse olfactory bulb.||Genes Cells (2015).(26522736)|
|Ohba K, Takeda K, Yamamoto H, Shibahara S.|