|Former Common name||mt-KITV620A Tg-4 BDF1 x B6|
|H-2 Haplotype||No Data|
|Genotype||a/a B/B C/C +/+|
|2||Appearance||black with large white spot|
|Genotype||a/a B/B C/C Tg/+|
|Strain development||Developed by Takahiro Kunisada at Gifu University school of medicine in 2004. The mouse Val 620 Ala mutated Kit gene was injected into the pronuclei of B6D2F1 fertilized eggs. The transgenic mice were backcrossed to C57BL/6.|
|Strain description||These transgenic mice express the Val 620 Ala mutated Kit gene. Mice carrying the transgene show white spots on 70-90% of the body hair. This strain is useful for the study of Kit gene function.|
|Colony maintenance||Backcross to C57BL/6J (Hemizygote x C57BL/6JJcl)
Mice carrying the transgene show white spots on 70-90% of the body hair.
|Health Report||No Data|
|Promoter||mouse MT-I promoter, human growth hormone poly A, 5′ and 3′ flanking regions of mouse MT gene|
|Symbol name||kit oncogene|
|Common name||mouse c-kit cDNA (Val 620Ala )|
|Symbol description||No Data|
|References||J Invest Dermatol. 2006 May;126(5):1111-8.
Mice transgenic for Kit(V620A): recapitulation of piebaldism but not progressive depigmentation seen in humans with this mutation.
|Research applications||Cancer Research,
Cell Biology Research
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on
use of it from the DEPOSITOR. The RECIPIENT is requested to include the
DEPOSITOR as a co-author in the first publication resulted by the use of the
BIOLOGICAL RESOURCE provided within two years after the deposition to the
RIKEN BRC. After acceptance of the first paper the DEPOSITOR only requests
the RECIPIENT to cite the first paper by the DEPOSITOR in any publication.
|1||Lab HP (Japanese)|
|2||Genotyping protocol <PCR>|
|Depositor||Kunisada, Takahiro (Gifu University, Graduate School of Medicine)|
|Strain Status /