Strain Information | |
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Image | |
BRC No. | RBRC01300 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | D2.Cg-Prkdc<scid>/Rbrc |
Former Common name | DBA/2-scid/+, DBA/2-scid mice |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Mie University Graduate School of Medicine. The original scid mice were provided by Ohtura Niwa, Radiation Biology Center, Kyoto University (C57BL/6-scid p<un>). The mutant mice were backcrossed to DBA/2Cr and C57BL/6NCr (RBRC01300 and RBRC01346, respectively). |
Strain description | scid, severe combined immune deficiency mice. Homozygous mutant mice lack both functional T and B cells, resulting in severe combined immunodeficiency. DBA/2 background (RBRC01300), C57BL/6 background (RBRC01346). We do not carry out a detection of leaky mice by measuring serum Ig level (PCR genotying of scid mutation only). |
Colony maintenance | Homozygote x Homozygote [or Crossing to DBA/2CrSlc] |
References | Proc. Natl. Acad. Sci. USA, 94, 2438-2443 (1997). 9122213 Radiat. Res., 157, 661-667(2002). 12005545 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Prkdcprotein kinase, DNA activated, catalytic polypeptide16Prkdc<scid>severe combined immune deficiency |
Ordering Information | |
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Donor DNA | |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for basic research, shall not use for commercial use. |
Depositor | Kagemasa Kuribayashi (Mie University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |