RBRC01420, B6;129P2-Irf7<tm1Ttg>/TtgRbrc

RBRC No. RBRC01420
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129P2-Irf7<tm1Ttg>/TtgRbrc
Former Common name IRF-7-KO, IRF7, IRF-7 knockout mice, C57BL/6J
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Donor strain 129P2/OlaHsd via E14.1 ES cell line
Background strain C57BL/6J
1 Appearance black
Genotype a/a
Strain development Developed by Kenya Honda and Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo in 2001. The knockout construct was electroporated into E14 ES cells derived from 129P2/OlaHsd. C57BL/6 semicongenic strain.
Strain description IRF7 knockout mice. Exon 2 and 3 of Irf7 gene were replaced with a PGK-beta-geo cassette. Homozygous mutant mice are vulnerable to viral infection with a decreased serum interferon level.
Colony maintenance Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
2 Symbol Irf7
Symbol name interferon regulatory factor 7
Chromosome 7
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 7
Common name No Data
Symbol description E. coli beta galactosidase
References Nature. 2005 Apr 7;434(7034):772-7. Epub 2005 Mar 30.

Research applications Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 Mouse of the Month May 2005
Genetic Background
2 Taniguchi Lab HP
3 Genotyping protocol <PCR>
Depositor Taniguchi, Tadatsugu (The University of Tokyo, Graduate School of Medicine) Taniguchi, Tadatsugu
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live mouse :
BRC mice in Publications
Title Journal
Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol.178(11): 6876-85 (2007).(17513736)
Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR.
Stromal cell-mediated suppression of human T-cell leukemia virus type 1 expression in vitro and in vivo by type I interferon. J Virol.83(10): 1167893 (2009).(19264779)
Kinpara S, Hasegawa A, Utsunomiya A, Nishitsuji H, Furukawa H, Masuda T, Kannagi M.
Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7. PLoS Pathog.6(3): e1000813 (2010).(20300600)
Phillips R, Svensson M, Aziz N, Maroof A, Brown N, Beattie L, Signoret N, Kaye PM.
Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis. Toxicol Sci.116(2): 682-92 (2010).(20513754)
Giordano G, van den Br le S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, Couillin I, Ryffel B, Michiels T, Renauld JC, Lison D, Huaux F.
Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. J Immunol.185(2): 1258-64 (2010).(20562259)
Khorooshi R, Owens T.
Interferon regulatory factor 7 contributes to the control of Leishmania donovani in the mouse liver. Infect Immun.79(3): 1057-66 (2011).(21149596)
Beattie L, Phillips R, Brown N, Owens BM, Chauhan N, Dalton JE, Kaye PM.
IRF3 protects from uterine horn pathology during Chlamydia muridarum genital infection in mice. Infect Immun. (2011).(21788382)
Prantner D, Sikes JD, Hennings L, Savenka AV, Basnakian AG, Nagarajan UM.
Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice. J Neuroinflammation.8: 181 (2011).(22196084)
Salem M, Mony JT, Lobner M, Khorooshi R, Owens T.
Differential impact of interferon regulatory factor 7 in the initiation of the type I interferon response in the LCMV infected CNS versus the periphery. J Virol. (2012).(22514347)
Christensen JE, Fenger C, Issazadeh-Navikas S, Krug A, Liljestr m P, Goriely S, Paludan SR, Finsen B, Christensen JP, Thomsen AR.
Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection. J Virol.86(20): 11254-65 (2012).(22875973)
Zhou S, Cerny AM, Fitzgerald KA, Kurt-Jones EA, Finberg RW.
Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. Virology.439(2): 152-62 (2013).(23490048)
Li W, Hofer MJ, No on AL, Manders P, Campbell IL.
Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance. Am J Physiol Endocrinol Metab.305(4): E485-95 (2013).(23695216)
Wang XA, Zhang R, Zhang S, Deng S, Jiang D, Zhong J, Yang L, Wang T, Hong S, Guo S, She ZG, Zhang XD, Li H.
Li W, Hofer MJ, Jung SR, Lim SL, Campbell IL.
TLR9 and STING agonists synergistically induce innate and adaptive type II IFN. Eur J Immunol. (2014).(25529558)
Temizoz B, Kuroda E, Ohata K, Jonai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ.
IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections. Sci Transl Med.8(336): 336ra59. (2016).(27122612)
Puthia M, Ambite I, Cafaro C, Butler D, Huang Y, Lutay N, Rydström G, Gullstrand B, Swaminathan B, Nadeem A, Nilsson B, Svanborg C.