RBRC01489, B6.129P2-Ptprt<tm1Sata>/SataRbrc

RBRC No. RBRC01489
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Ptprt<tm1Sata>/SataRbrc
Former Common name PTP rho KO 231
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Donor strain 129P2/OlaHsd via E14 ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Masanobu Satake, Tohoku University. C57BL/6 background.
Strain description PTP rho, Protein tyrosine phospatase receptor type T, is a member of the receptor tyrosine phosphatase family. PTPs are signaling molecules that regulate a variety of cellular processes including mitotic cycle, cell growth, differentiation, and oncogenic transformation. At present, homozygous mutant mice show no abnormality.
Colony maintenance backcross to C57BL/6 (Heterozygote x C57BL/6J)
Health Report
Gene Details
Promoter No Data
1 Symbol Ptprt
Symbol name protein tyrosine phosphatase, receptor type, T
Chromosome 2
Common name RPTPrho
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to include the DEPOSITOR as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Satake, Masanobu (Institute of Development, Aging and Cancer, Tohoku University) Satake, Masanobu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
PTPRT regulates high-fat diet-induced obesity and insulin resistance. PLoS One. (2014).(24949727)
Feng X, Scott A, Wang Y, Wang L, Zhao Y, Doerner S, Satake M, Croniger CM, Wang Z.