|Former Common name||Bipolar Disorder Model Mouse|
|H-2 Haplotype||No Data|
|Strain development||Developed by Drs. Takaoki Kasahara and Tadafumi Kato at RIKEN BSI in 2001. The mutant POLG coding fragment including the CaMKII alpha promoter was injected into the pronuclei of C57BL/6J fertilized eggs.|
|Strain description||Bipolar disorder, a mood disorder marked by alternating periods of manic and depressive episodes, affects approximately 1% of the global population. Mitochondrial dysfunction has been seen in patients with bipolar disorder. Moreover, patients with mitochondrial disorders sometimes display mood disorders. This transgenic mice express mouse mitochondrial DNA polymerase (POLG) having a point mutation D181A under the control of CaMKII alpha promoter. The mutant mice exhibited characteristic behavioral phenotypes in accordance with criteria for the validation as an animal model of mood disorder. This strain is useful to investigate the cause of bipolar disorder and to develop new mood stabilizers to treat bipolar disorder.|
|Colony maintenance||Backcross to C57BL/6 (hemizygote male x 57BL/6JJcl female)
Don’t use Tg female for breeding in order to prevent transmission of mutated mtDNA.
|Promoter||mouse Camk2a promoter|
|Symbol name||polymerase (DNA directed), gamma|
|Common name||mitochondrial DNA polymerase gamma, mitochondrial DNA polymerase-gamma, Pol gamma, Polga, polymerase gamma|
|Symbol description||No Data|
|References||Mol Psychiatry. 2006 Jun;11(6):577-93.
Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes.
|Research applications||Cell Biology Research,
Mouse Models for Human Disease
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Molecular Psychiatry, 11, 577-593 (2006).
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.
The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE when the RECIPIENT ordered the BIOLOGICAL RESOURCE before the publication of the paper indicated above.
|1||Mouse of the Month May 2006|
|3||Genotyping protocol <PCR>|
|Depositor||Kato, Tadafumi (RIKEN Center for Brain Science)|
|Strain Status /