RBRC01707, B6.Cg-Tg(Mt1-RET)192Ina

RBRC No. RBRC01707
Type TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Tg(Mt1-RET)192Ina
Former Common name 192 RET
H-2 Haplotype No Data
Background strain No Data
1 Appearance No Data
Genotype No Data
Strain development Developed by Masashi Kato, Nagoya University Graduate School of Medicine. The transgene was injected into the pronuclei of (BALB/c x C57BL/6) x BALB/c fertilized eggs. C57BL/6 and BALB/c mixed background.
Strain description This strain expresses the human RET gene under the control of the mouse Mt1 promoter/enhancer. This Mt1-RET 192 line develops benign tumors 100% within several months after birth. However they never transform to malignant tumors. Crossing with C57BL/6 multiple times makes this strain more difficult to maintain because of the earlier onset of tumors.
Colony maintenance Carrier x Noncarrier
Health Report
Gene Details
Promoter No Data
1 Symbol Tg(Mt1-RET)192Ina
Symbol name transgene insertion 192, Izumi Nakashima
Chromosome UN
Common name Tg(Mt1-RET)192Num, Tg(Mt1-RFP/RET)192Num
Symbol description No Data
2 Symbol No Data
Symbol name SV40 splicing signal-polyadenylation site
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse metallothionein 1 promoter/enhancer
3 Symbol RET
Symbol name recombinant RET proto-oncogene (human)
Chromosome UN
Common name RET51, RET9
Symbol description No Data
References EMBO J. 1991 Nov;10(11):3167-75.

Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.
Research applications Cancer Research,
Dermatology Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Kato, Masashi (Chubu University College of Life and Health Sciences) Kato, Masashi
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months