RBRC01709, B6.Cg-Tg(Mt1-RET)304Ina/B6

RBRC No. RBRC01709
Type TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Tg(Mt1-RET)304Ina/B6
Former Common name 304-B6 RET
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C +/+
2 Appearance black with black skin (hyperpigmented skin)
Genotype a/a B/B C/C Tg/+
Strain development Developed by Masashi Kato, Nagoya University Graduate School of Medicine. The Mt1-RET transgene was injected into the fertilized eggs of (BALB/c x C57BL/6) x BALB/c mice. C57BL/6 and BALB/c mixed background.
Strain description Mt1-Ret 304 transgenic mice. The mice express the human RET under the control of the mouse MT1 promoter/enhancer. This Mt1-RET 304 strain is a model of cutaneous melanosis, and develops benign tumors 100% on the skin. Of these tumors, 65% transform to malignant tumors in ten to twelve months after the birth. Tg homozygous mice are embryonic lethal.
Colony maintenance Carrier x Noncarrier
Health Report
Gene Details
Promoter No Data
1 Symbol Tg(Mt1-RET)304Ina
Symbol name transgene insertion 304, Izumi Nakashima
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol No Data
Symbol name SV40 splicing signal-polyadenylation site
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse metallothionein 1 promoter/enhancer
3 Symbol RET
Symbol name recombinant RET proto-oncogene (human)
Chromosome UN
Common name RET51, RET9
Symbol description No Data
References EMBO J. 1991 Nov;10(11):3167-75.

Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.
Research applications Cancer Research,
Dermatology Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Kato, Masashi (Chubu University College of Life and Health Sciences) Kato, Masashi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months