RBRC01765, B6.129S4-Tob1<tm1Tya>/TyaRbrc

RBRC No. RBRC01765
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name B6.129S4-Tob1<tm1Tya>/TyaRbrc
Former Common name tob-gene KO (B6)
H-2 Haplotype No Data
ES cell line J1 [129S4/SvJae]
Background strain C57BL/6
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Tetsuo Noda at Japanese Foundation for Cancer Research Cancer Institute and Dr. Tadashi Yamamoto at the University of Tokyo in 1997. A PGK-neo cassette was inserted into the cording region of Tob1 gene. C57BL/6J background.
Strain description Tob is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob1 null mice are viable and exhibit bone mass due to increased numbers of osteoblasts. This strain is useful for elucidating of Tob gene function.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
Health Report
Gene Details
Promoter No Data
1 Symbol Tob1
Symbol name transducer of ErbB-2.1
Chromosome 11
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
References Cell. 2000 Dec 22;103(7):1085-97.
Genes Dev. 2003 May 15;17(10):1201-6.

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Yamamoto, Tadashi (The Institute of Medical Science, The University of Tokyo) Yamamoto, Tadashi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med. (2013).(23797093)
Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE.
Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci. Rep. (2016).(27546286)
Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE.