RBRC01767, B6.129S4-Tob1<tm1Tya> Tob2<tm1Tya>/TyaRbrc

RBRC No. RBRC01767
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name B6.129S4-Tob1<tm1Tya> Tob2<tm1Tya>/TyaRbrc
Former Common name tob and tob2 KO (B6)
H-2 Haplotype No Data
Background strain C57BL/6
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute at and Dr. Tadashi Yamamoto at the University of Tokyo. This strain was produced by crossing Tob1 KO mice and Tob2 KO mice.
Strain description Tob is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob1 null mice are viable and exhibit bone mass due to increased numbers of osteoblasts. While, Tob2 null mice appear normal. This strain is useful for elucidating of Tob gene function.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
Health Report
Gene Details
Promoter No Data
1 Symbol Tob1
Symbol name transducer of ErbB-2.1
Chromosome 11
Common name No Data
Symbol description No Data
2 Symbol Tob2
Symbol name transducer of ErbB-2.2
Chromosome 15
Common name No Data
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 15
Common name No Data
Symbol description E. coli beta galactosidase
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Yamamoto, Tadashi (The Institute of Medical Science, The University of Tokyo) Yamamoto, Tadashi
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months