RBRC01772, B6.129S2-Tmbim1<tm1Noj>/41

RBRC No. RBRC01772
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129S2-Tmbim1<tm1Noj>/41
Former Common name RECS1 KO
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain C57BL/6
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hanjun Zhao, Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2001. D3 ES cells were used to generate the knockout mice. The mutant mice were backcrossed to C57BL/6 over 8 times.
Strain description RECS1 (Tmbim1) gene knockout mice. The 5'-untranslated sequence (-3.8 kb) and exon 1-6 region of RECS1 was replaced by PGK-neo cassette. Homozygous mutant mice are prone to aortic dilation and cystic medial degeneration (CMD) when the mice ages (older than 14 months). Aortic dilation and CMD are frequently encountered. Viable and fertile.
Colony maintenance Heterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Tmbim1
Symbol name transmembrane BAX inhibitor motif containing 1
Chromosome 1
Common name RECS1
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References Genes Genet Syst. 2006 Feb;81(1):41-50.

RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.
Research applications Cardiovascular Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
RECS1 deficiency in mice induces susceptibility to cystic medical degeneration. Hanjun Zhao et al. (2006) Genes Genet. Syst. 81, p41-50
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Mouse of the Month Jan 2007
2 Genotyping protocol <PCR>
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months