RBRC01817, B6.129P2-Drd4<tm1(IL2RA)Tao>/KobaRbrc

RBRC No. RBRC01817
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129P2-Drd4<tm1(IL2RA)Tao>/KobaRbrc
Former Common name D4R-IL-2R
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Kazuto Kobayashi, Fukushima Medical University School of Medicine in 1998.
Strain description B6.129P2-Drd4<tm1(IL2RA)Tao. The human interleukin-2 receptor alpha-subunit gene and neo cassettes were introduced into exon 2 of mouse D4R gene. Specific neurons expressing D4R gene of this mice are disrupted by a recombinant immunotoxin.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
Health Report
Gene Details
Promoter No Data
1 Symbol Drd4
Symbol name dopamine receptor 4
Chromosome 7
Common name D4R, Drd-4
Symbol description No Data
2 Symbol HBB2
Symbol name rabbit beta-globin poly A
Chromosome 7
Common name No Data
Symbol description No Data
3 Symbol IL2RA
Symbol name Interleukin-2 receptor α-subunit (human)
Chromosome 7
Common name No Data
Symbol description No Data
4 Symbol poly A
Symbol name SV40
Chromosome 7
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
References J Neurosci. 2003 Dec 17;23(37):11662-72.

Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons.
Research applications Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. Shin R-M, Masuda M, Miura M, Sano H, Shirasawa T, Song WJ, Kobayashi K, Aosaki T. J. Neurosci. 23 (37) 11662-11672 (2003).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Kobayashi, Kazuto (Fukushima Medical University) Kobayashi, Kazuto
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months