RBRC01841, B6.Cg-Tg(hGOS2)3Noj

RBRC No. RBRC01841
Type TransgeneCartagena wks
Species Mus musculus
Strain name B6.Cg-Tg(hGOS2)3Noj
Former Common name AILE1 TG (ATG3)
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. The transgene was injected into the pronuclei of B6D2F1 fertilized eggs. C57BL/6 and DBA/2 mixed (B6 semicongenic).
Strain description These transgenic mice express human GOS2 (AILE1) gene that was a gene identified as systemic lupus erythematosus (SLE)-upregutated gene by microarray screening.
Colony maintenance Carrier x Noncarrier [C57BL/6NCrSlc]
Health Report No Data
Gene Details
Promoter CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
1 Symbol AILE1
Symbol name augmented expression in SLE
Chromosome UN
Common name No Data
Symbol description No Data
References DNA Res. 2005;12(6):429-39. Epub 2006 Feb 23.

Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.
Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.
Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
DNA Res., 12, 429-439 (2005).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months