|Former Common name||B6; C3;B6-Mitf-mibw/mibw|
|H-2 Haplotype||No Data|
|Background strain||No Data|
|Strain description||The Mitf, microphthalmia-associated transcription factor plays a critical role in the development of melanocytes, mast cells, osteoclasts and pigmented epithelium. Homozygous mice for the Mitf<mi-bw> mutation display a white coat with black eyes. In this allele, a L1 element was inserted into intron 3. This strain is useful as an animal model for Waardenburg syndrome type 2 (WS2).|
|Colony maintenance||Sibling Mating (Homozygote x Homozygote)|
|Symbol name||microphthalmia-associated transcription factor|
|Common name||mi, wh|
|Symbol description||No Data|
|References||Hum Mol Genet. 1999 Aug;8(8):1431-41.
An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness.
|Research applications||Dermatology Research,
Mouse Models for Human Disease
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Hum. Mol. Genet., 8, 1431-1441 (1999).
|1||Mouse of the Month Dec 2006|
|Depositor||Yamamoto, Hiroaki (Nagahama Institute of Bio-Science and Techology)|
|Strain Status /