|Former Common name||IL-5 Transgenic mice|
|H-2 Haplotype||No Data|
|Strain development||Generated by Kiyoshi Takatsu, Kumamoto University Medical School. The transgene was injected into the pronuclei of C3H fertilized eggs. C57BL/6 (RBRC01908) and BALB/c (RBRC05910) background (Developed by Institute of Medical Science, University of Tokyo), NZW background (RBRC01200) (Developed by Juntendo University School of Medicine).|
|Strain description||Mt1-Il5 transgenic mice. These transgenic mice express mouse IL-5 under the control of the Mt1 promoter.|
|Colony maintenance||Carrier x Carrier (Homozygous x Homozygote) Tg mice show no obvious abnormality.|
|Symbol name||interleukin 5|
|Common name||No Data|
|Symbol description||No Data|
|References||J Exp Med. 1991 Feb 1;173(2):429-37.
Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.
|Research applications||Immunology and Inflammation Research|
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Exp. Med., 173, 429-437 (1991).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
|2||Genotyping protocol <PCR>|
|Depositor||Takatsu, Kiyoshi (The Institute of Medical Science, The University of Tokyo)|
|Strain Status /
|Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.||FASEB J. (2014).(24891522)|
|Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M.|
|The Development of Mixed Cryoglobulinemia in Capillaria hepatica-Infected Mice Is Associated with the Capillaria Antigen-Induced Selective Proliferation of Splenic B-1a Cells in Response to Interleukin-5 Stimulation.||Am J Pathol. (2014).(25452118)|
|Aihara N, Kamiie J, Yamada M, Shirota K.|