RBRC01908, B6.Cg-Tg(Mt1-Il5)6Ato

RBRC No. RBRC01908
Type Transgene CongenicCartagena wks
Species Mus musculus
Strain name B6.Cg-Tg(Mt1-Il5)6Ato
Former Common name IL-5 Transgenic mice
H-2 Haplotype No Data
Background strain C57BL/6
Appearance
1 Appearance No Data
Genotype No Data
Strain development Generated by Kiyoshi Takatsu, Kumamoto University Medical School. The transgene was injected into the pronuclei of C3H fertilized eggs. C57BL/6 (RBRC01908) and BALB/c (RBRC05910) background (Developed by Institute of Medical Science, University of Tokyo), NZW background (RBRC01200) (Developed by Juntendo University School of Medicine).
Strain description Mt1-Il5 transgenic mice. These transgenic mice express mouse IL-5 under the control of the Mt1 promoter.
Colony maintenance Carrier x Carrier (Homozygous x Homozygote) Tg mice show no obvious abnormality.
Health Report
Gene Details
Promoter metallothionein 1
1 Symbol Il5
Symbol name interleukin 5
Chromosome UN
Common name No Data
Symbol description No Data
References J Exp Med. 1991 Feb 1;173(2):429-37.

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Exp. Med., 173, 429-437 (1991).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takatsu, Kiyoshi (The Institute of Medical Science, The University of Tokyo) Takatsu, Kiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J. (2014).(24891522)
Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M.
The Development of Mixed Cryoglobulinemia in Capillaria hepatica-Infected Mice Is Associated with the Capillaria Antigen-Induced Selective Proliferation of Splenic B-1a Cells in Response to Interleukin-5 Stimulation. Am J Pathol. (2014).(25452118)
Aihara N, Kamiie J, Yamada M, Shirota K.