RBRC01916, pKF1KO4.3.1

RBRC No. RBRC01916
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name pKF1KO4.3.1
Former Common name Hicky mouse
H-2 Haplotype No Data
Background strain No Data
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Tamotsu Hashimoto-Gotoh at Kyoto Prefectural University of Medicine in 2001.
Strain description The kf-1 gene was first discovered as a cDNA clone whose mRNA synthesis is elevated in the cerebral cortex of Alzheimer’s disease patient (1), and identified later in the rat cerebral cortex after repeated electroconvulsive treatment and chronic antidepressant treatment with SSRI (2). The KF-1 protein is one of the Zinc finger proteins belonging to the RING H2 family, which have been assessed for their ability to facilitate E2-dependent ubiquitination (3). Cells that express exogenous kf-1 result in apoptotic cell death in vitro (unpublished data). Kf-1 deficient mice, called “hicky” mice (“hicky” means hikikomori symptome in Japanese slung, which resembles to “social withdrawal” in English.), display typical anxiety-like behaviors without any other major abnormalities including pathological, physical, behavioral and reproductive aspects.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6NJcl)
Health Report
Gene Details
Promoter No Data
1 Symbol Rnf103
Symbol name ring finger protein 103
Chromosome 6
Common name kf-1, Zfp103
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 6
Common name No Data
Symbol description No Data
References Front Behav Neurosci. 2008;2:4. Epub 2008 Sep 8.

Mice Lacking the kf-1 Gene Exhibit Increased Anxiety- but not Despair-Like Behavior.
Research applications Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Front. Behav. Neurosci., 2, 3389- (2008).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 Mouse of the Month Apr 2007
2 Genotyping protocol <PCR>
Depositor Hashimoto-Gotoh, Tamotsu (Kyoto Prefectural University of Medicine) Hashimoto-Gotoh, Tamotsu
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior. Front Behav Neurosci.2: 4 (2008).(18958194)
Tsujimura A, Matsuki M, Takao K, Yamanishi K, Miyakawa T, Hashimoto-Gotoh T.