RBRC02102, B6.Cg-Arpc3<tm1Jtak>/JtakRbrc

RBRC No. RBRC02102
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.Cg-Arpc3<tm1Jtak>/JtakRbrc
Former Common name Arpc3-KO
H-2 Haplotype No Data
Background strain No Data
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Junji Takeda at Osaka University in 2005. A PGK-neo selection cassette replaced a fragment of exon 2 of Arpc3 gene.
Strain description Arpc3 is a component of the Arp2/3 complex, which plays a major role in actin nucleation, filament binding, and Y-shaped branching to reorganize filamentous actin in response to extrinsic or intrinsic signaling for cell motility.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6J)
Health Report
Gene Details
Promoter No Data
1 Symbol Arpc3
Symbol name actin related protein 2/3 complex, subunit 3
Chromosome 5
Common name 1110006A04Rik, Arp2/3 complex subunit p21-Arc, p21-Ar
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
References Mol Cell Biol. 2006 Aug;26(16):6185-96.

Sleeping beauty transposon-based phenotypic analysis of mice: lack of arpc3 results in defective trophoblast outgrowth.
Research applications Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Molecular and Cellular Biology, 26, 6185-6196 (2006).
RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University.
Additional information
1 Takeda Lab HP
2 Genotyping protocol <PCR>
Depositor Takeda, Junji (Osaka University) Takeda, Junji
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months