|Former Common name||p38α-flox mouse|
|H-2 Haplotype||No Data|
|ES cell line||R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]|
|Genotype||a/a B/B C/C|
|Strain development||Developed by Kinya Otsu, Osaka University Graduate School of Medicine in 2000. The targeting construct was electoroporated into R1 ES cells derived from (129X1/SvJ x 129S1/Sv)F1-Kitl<+>. The mutant mice were backcrossed to C57BL/6J.|
|Strain description||Mitogen-activated protein (MAP) kinase cascades are highly conserved signal transduction pathways involved in a variety of physiological events. The MAP kinase family consists of extracellular signal-regulated protein kinase (ERK), c-Jun NH2-terminal protein kinase (JNK), and p38 MAP kinase. p38 alpha, one of the p38 MAP kinase subfamily, is widely expressed and has an important function in cytokine production and the response to many types of stress. Because p38alpha-deficient mice (BRC00361 C57BL/6-TgH(p38)/118) showed embryonic lethality at midgestation, this strain is useful for the research of p38 MAP kinase pathway in various tissues using Cre-loxP system.|
|Colony maintenance||Homozygote x Homozygote [or Crossing to C57BL/6JJcl]. Homozygous mutant mice are viable and fertile.|
|Symbol name||mitogen activated protein kinase 14|
|Common name||Crk1, Csbp1, CSBP2, Mxi2, p38, p38 MAP Kinase, p38-alpha, p38MAPK, tRNA synthetase cofactor p38|
|Symbol description||No Data|
|Symbol name||phage P1 loxP|
|Common name||No Data|
|Symbol description||No Data|
|References||Mol Cell Biol 2004 Dec;24(24):10611-20.
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.
|Research applications||Cell Biology Research,
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Biol., 24, 10611-10620 (2004).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
|1||Mouse of the Month Jul 2007
|2||Lab HP (Japanese)|
|3||Genotyping protocol <PCR>|
|Depositor||Otsu, Kinya (King’s College London)|
|Strain Status /
|Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.||Nat Immunol.13(5): 457-64 (2012).(22447027)|
|Liu X, Ma B, Malik AB, Tang H, Yang T, Sun B, Wang G, Minshall RD, Li Y, Zhao Y, Ye RD, Xu J.|
|Mice with a Conditional Deletion of the Neurotrophin Receptor TrkB Are Dwarfed, and Are Similar to Mice with a MAPK14 Deletion.||PLoS One.8(6): e66206 (2013).(23776632)|
|Sex-specific control of CNS autoimmunity by p38 MAPK signaling in myeloid cells.||Ann Neurol. (2013).(24027119)|
|Krementsov DN, Noubade R, Dragon JA, Otsu K, Rincon M, Teuscher C.|
|Deficiency of Neuronal p38 MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.||J. Biol. Chem.291(5): 2067-2079 (2015).(26663083)|
|Schnöer L, Hao W, Qin Y, Liu S, Tomic I, Liu X, Fassbender K, Liu Y.|