RBRC No. RBRC02217
Type TransgeneCartagena
Species Mus musculus
Strain name STOCK Tg(MoMuLV/RET-MEN2A)121Mat
Former Common name Tg2A-121
H-2 Haplotype No Data
Background strain No Data
1 Appearance black (a/a B/? C/C)
Genotype No Data
2 Appearance brown (a/a b/b C/C)
Genotype No Data
Strain development Developed by Dr. K. Kawai, Nagoya University School of Medicine in 1999. C57BL/6 and BALB/c mixed background.
Strain description This transgenic mouse was generated by introducing RET with a MEN2A (cysteine 634 arginine) mutation fused to Moloney murine leukemia virus long terminal repeat. The heterozygous mice develop thyroid C-cell hyperplasia or medullary carcinoma.
Colony maintenance Sibling Mating (Heterozygote x Wild-type)
Health Report
Gene Details
Promoter No Data
1 Symbol polyA
Symbol name rat insulin
Chromosome UN
Common name No Data
Symbol description No Data
Promoter MoMuLV LTR
2 Symbol RET
Symbol name recombinant RET proto-oncogene (human)
Chromosome UN
Common name human RET cDNA with a MEN2A (Cys634Arg) mutation
Symbol description No Data
References Cancer Res. 2000 Sep 15;60(18):5254-60.

Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.
Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cancer Researh, 60, 5254-5260 (2000).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takahashi, Masahide (Nagoya University) Takahashi, Masahide
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months